关键词: <, p>, 二氮嗪, 骨关节炎, 氧化损伤, 线粒体ATP 敏感钾通道<, /p>

Abstract: Abstract: Objective To study the effects of diazoxide on the knee osteoarthritis in rabbits and explore the possible mechanism． Method Select 20 adult male New Zealand white rabbits，cut off the bilateral anterior cruciate ligament of knee joint and the lateral meniscus，establish the model of osteoarthritis; randomly devide the rabbits into diazoxide group and control group，10 rabbits per group，Every week after the surgery，give the former diazoxide 1 mL injection in the intra-articular，give the control group distilled water 1 mL injection in the intraarticular．Anatomize the rabbit knee joint at the fourth week，and compare the cartilage lesion of the two groups．Ｒesult Observing the animal’s capability of motion and rabbit knee specimen，we found the osteoarthritis pathological changes in Diazoxide group is lighter than in control group ( P ＜ 0. 05) ． Conclusion Diazoxide has acertain antagonism to the development of osteoarthritis of the knee joint in rabbits．

Key words: <p>Diazoxide, osteoarthritis, oxidative damage, mitochondria ATP sensitive potassium channel</p>