关键词: <, p>, H-1 细小病毒, C6 细胞, 细胞因子<, /p>

Abstract: Abstract: Objective To investigate the changes of cytokine levels after the infection of rat glioma cells C6 by H-1 parvovirus． Method C6 cells were taken after infection H-1 parvovirus at different time points，while the normal C6 cells were taken in these time points，and the ELISA． Methods were used to detect the expression levels of TNFα，IL-6，TGF-β1 and IL-17A． Result The concentrations of TNF-α，TGF-β1 and IL-17A in C6 cells were increased during culture，and which of IL-6 was no significant change; The concentrations of TNF-α，TGF-β1 and IL-17A in H-1 parvovirus infected C6 cells were no significant change，while IL-6 concentration was significantly increased over time． Conclusion H-1 parvovirus infection leads to changes in C6 cytokine expression levels．

Key words: <p>H-1 parvovirus, rat Glioma cells C6, cytokine</p>