关键词:

小型猪, 可复性肺不张, 模型

Abstract: Abstract: Objective To establish an experimental model for reversible atelectasis of minipig． Method Twelve male China Experimental Miniature Pig( CEMP) were divided into two groups randomly: atelectasis group( A group) and reversible atelectasis group( Ｒ group) ． Ni-Ti alloys occluders were placed in the lower right main bronchus of all animals with a bronchofiberscope after anesthesia． The occluders were pulled out by bronchofiberscope after atelectasis confirmed after three days in Ｒ group． The development of atelectasis/reexpansion was studied by computerized tomography scanning every three days after occluders were placed in or pulled out． All of the group A animals were sacrificed on the third day after established atelectasis，and CEMP of group Ｒ were killed at two weeks． Ｒesult Typical pathology of atelectasis and computerized tomography imaging were observed in group A， and all changes alleviated obviously in group Ｒ，tended to be normal． Conclusion CEMP could be used as an ideal model for reversible atelectasis created by placing in /pulling out Ni-Ti alloys occluder in the lower right main bronchus by bronchofiberscope．

Key words: CEMP, reversible atelectasis;model