关键词: p53 基因敲除小鼠, 生长发育, 繁殖性能

Abstract: Abstract: Objective To investigate the differences in growing development and reproductive performance between p53 knockout mice and BALB /c mice． Method 34 p53 knockout mice with half males and half females and 34 BALB /c mice ( half male and female) were adopted in the trial，and their body weight and body length were measured from 2 to 12 weeks of age． Litter sizes at the second parity from 30 pairs of mice were checked． Result The difference in body weight between 3 － week old p53 knockout mice and BALB /c mice was not significant ( P ＞ 0. 05) ，and body weight of 6 － week old p53 knockout mice was significantly lower than that of 6 － week old BALB /c mice ( P ＜ 0. 05) ． Body length of 3 － week and 6 － week old p53 knockout mice was significantly lower than that of 3 － week and 6 － week old BALB /c mice ( P ＜ 0. 05) ． Reproductive performance of p53 knockout mice was significantly lower than that of BALB /c mice ( P ＜ 0. 05) ． Conclusion p53 gene knockout could exert significant effect on the growing development and reproductive performance of the mice．

Key words: p53 knockout mice, growing development, reproductive performance