关键词: 小鼠, 实验动物, 繁殖性能

Abstract: Objective　The reproductive performance of BALB/c-nu mice, NOD SCID mice, C.B17 SCID mice, NTG mice and APOE mice were measured and analyzed, which provided data support for the biological characteristics of the above five strains of mice.Methods　Five kinds of SPF inbred mice, 6 pairs in each group, were bred continuously by long-term cohabitation and mating of all siblings in a ratio of 1 ∶ 1. The average litter size, average weaning number, weaning rate, sex ratio, average litter interval of mating strains of mice aged 8-12 weeks, first birth interval and litter interval were measured respectively.Results　The average litter size of BALB/c-nu mice is 6-8, and the weaning rate is 98% 100%. The average litter size of NOD SCID mice is 5-6, and the weaning rate is 77%-97%. The average litter size of C.B17-SCID mice is 4-5, and the weaning rate is 88%-99%. The average litter size and the average weaning number of all strains of animals increased or tended to be stable in the second and third litters (P<0.05), but decreased in the fourth litter (P<0.05) and obviously decreased in the fifth fetus (P<0.05).The age of first mating of five kinds of mice ranged from 56 to 82 d, and the average fetal interval was 32.11 d-44.20 d. The interval between primiparity of BALB/c-nu mice, NOD SCID mice, C.B17-SCID mice, NTG mice and APOE mice was 36.55 d, 45.10 d, 32.16 d, 36.37 d and 30.30 d respectively.Conclusion　It is best to select 8-week-old NOD SCID mice, 12-week-old C. B17-SCID mice, 8-week-old APOE mice, 11-week-old NTG mice and 9-week-old BALB/c-nu mice for mating and reproduction. The reproductive performance parameters obtained in this study provide basic data for mouse feeding management.

Key words: mouse, laboratory animals, reproductive performance