关键词: 母乳低聚糖, 坏死性小肠结肠炎, 动物模型, Meta分析

Abstract: Objective　A meta-analysis was conducted to study the effects of human milk oligosaccharides (HMOs) on necrotizing enterocolitis (NEC).Methods　PubMed, Embase, Web of Science, Cochrane library, OVID, Scopus, ProQuest, CNKI, Wanfang database, Weipu Periodical Database, Chinese Medical Journal Database, Chinese Biomedical Literature Database were searched for the randomized controlled animal studies of the effects of HMOs on animal models of NEC published up to August 2024. SYRCLE risk bias assessment tool was used to evaluate literature quality, and the RevMan 5.4 software was used for meta-analysis.Results　After strict inclusion and exclusion screening, a total of 6 studies were included, with a total of 175 animal models.The result of meta-analysis showed that compared with the control group, the NEC animal model in the HMOs group had lower mortality (RR=0.44,95%CI 0.24-0.81,P<0.01) and intestinal histopathological scores(MD=-1.44,95%CI -1.66--1.22,P< 0.001).Supplementation of disialyllacto-N-tetraose (DSLNT) alone could reduce NEC mortality (RR= 0.41,95%CI 0.17-0.97,P<0.05) and intestinal histopathological scores (MD=-1.54,95%CI -1.85--1.24,P<0.001).Conclusion　HMOs can reduce the mortality and intestinal histopathological scores associated with NEC animal models.

Key words: human milk oligosaccharides, necrotizing enterocolitis, animal models, Meta-analysis