关键词: 布氏田鼠, 低氧环境, 低氧环境适应性分子机制

Abstract: Lasiopodomys brandtii is a small rodent. Its natural ecological environment may fluctuate in the oxygen content in the cave due to seasonal changes. Especially during the rainy season and winter, a hypoxic environment is formed in the cave of Lasiopodomys brandtii. It must adopt certain adaptive strategies to maintain its survival. The adaptive mechanisms of Lasiopodomys brandtii in a hypoxic environment show highly complex physiological and molecular coordination. It enhances anaerobic metabolism, activates innate immune responses through oxygen transport and angiogenesis, and downregulates nerve synaptic transmission functions to reduce the body’s energy consumption to cope with hypoxic environments. The adaptive mechanism to the hypoxic environment not only reflects the ability of Lasiopodomys brandtii to adapt to the hypoxic environment, but also reveals the high degree of coordination formed by its physiological and metabolic systems during evolution. The purpose of this paper is to systematically review the adaptability of Lasiopodomys brandtii to hypoxic environment.

Key words: Lasiopodomys brandtii, hypoxic environment, molecular mechanisms of hypoxic environment adaptation