关键词: 气虚血瘀证, 动物模型, 病症结合, 大鼠, CiteSpace可视化分析

Abstract: Objective　To study the modeling characteristics of qi deficiency and blood stasis syndrome, providing reference for establishing stable and reliable animal models of qi deficiency and blood stasis syndrome.Methods　A systematic review was conducted on the research of animal models of qi deficiency and blood stasis syndrome. Relevant literature on animal models of qi deficiency and blood stasis syndrome was retrieved and a database was established. CiteSpace software was used to conduct visual analysis of animal models of qi deficiency and blood stasis syndrome. ResultsA total of 246 literatures were included in the study. The main experimental animals for qi deficiency and blood stasis syndrome were rats. The main modeling method is sleep deprivation. The combination of disease and syndrome, mainly cardiovascular and cerebrovascular diseases, is a current research hotspot. The future research trend might be the gut microbiota.Conclusion　By summarizing and analyzing the preparation method and research hotspots of the animal model of qi deficiency and blood stasis syndrome, this paper provides a reference for improving the success rate of the animal model, with the aim of laying a foundation for the study of qi deficiency and blood stasis syndrome and its combination of disease and syndrome.

Key words: Qi deficiency and blood stasis syndrome, animal model, combination of symptoms, rat, CiteSpace visual analysis