关键词: 关键词:脐疝, 动物模型, 表型特征, 生长曲线, 脏器系数, 血常规, 血液生化指标

Abstract: Abstract:Objective To observe the phenotypes and biological characteristics of the umbilical hernia ( UH) rat model. Method The spontaneous UH rat model was inbred by the whole sibling mating method, and the heritable UH rat model was established. Biological characteristics, such as phenotypic characteristic, growth curve, organ coefficient, blood routine examination items and blood biochemical indices, were observed and compared with SD rats. Result The incidence of umbilical hernia in cultivated UH rats maintained 100%, and the appearance, anatomy and pathology features were obvious. Male body weight was lower than that of SD rats at the same age from week 4, but there was no significant difference in female body weight. The spleen of UH rats was larger at the same age. Some blood routine examination items and blood biochemical indices were significantly different from those of SD rats. Conclusion Heritable UH rats have clear phenotypic characteristics and different biological characteristics from SD rats, which is expected to be a good animal model for studying the pathogenesis and susceptibility genes of umbilical hernia.

Key words: Key words:umbilical hernia, animal model, phenotypic characteristics, growth curve, organ coefficient, blood routine index, blood biochemical index