关键词: 黄甲软肝颗粒, 人血白蛋白, 免疫性肝纤维化, 肝纤维化, 大鼠

Abstract: Objective This study was designed to observe the protective effect of Huangjia Ruangan granules
against immune hepatic fibrosis induced by human serum albumin ( HSA) in rats. Method By vivo experiment,
72 male rats were randomly divided into the normal group, the model group, the positive group, the high-dose
group, the moderate-does group and the low-dose group of Huangjia Ruangan granules,n = 12. The rat model of
immune hepatic fibrosis induced by HSA was established. The effects were evaluated by liver and spleen index,
liver fibrosis markers, serum biochemical index and liver histopathological examination. Result The content of
HA in 3 groups of Huangjia Ruangan was significantly lower than this in the model group, the levels of LN, PC Ⅲ ,
the contents of ALT and AST in the high-dose group were significantly lower than those in the model group. The
degrees of liver fibrosis in the high-dose group and the moderate-dose group were significantly improved comparing
with the model group. Conclusion Huangjia Ruangan granules can significantly improve hepatic fibrosis in rats
induced by HSA.

Key words: Huangjia Ruangan granules, human serum albumin, immune hepatic fibrosis, hepatic fibrosis, rats