Abstract:Alzheimer’ s disease ( AD ) is a neurodegenerative disease that affects more than 40 million peopleworldwide and it is predicted to exponentially increase in the coming decades. The typical pathological feature of AD is the abnormal accumulation of neurotoxic amyloid beta ( Aβ) peptides in brain, the clinical manifestations including memory loss, cognitive regression and abnormal behavior. While AD pathophysiology has fundamentally been identified, the underlying mechanisms which leading to initial disease onset and disease progression still remain open to speculation. Because no curative treatment and lack of systematic and completed pathophysiological studies, animal models is the most valuable scientific tool for research. This article summarizes the details of some

kinds of genetic modified mouse models of AD, such as APP, PS, Apo E and ob genetic modified mice, and discusses the phenotypic characteristics, pathological changes and the application of them in the AD related research in a bid to provide references for the further studies on AD as well.