关键词: 糖尿病周围神经病变, 感觉功能检查, 病理学检查, 神经电生理, 运动功能检查, 角膜观察

Abstract: Diabetic peripheral neuropathy is a peripheral neurological dysfunction caused by sustained hyperglycemia that most commonly presents as distal degenerative neuropathy with abnormal pain, numbness and paresthesia and so on. Clinically, the diagnosis and treatment of DPN is still a great challenge in chronic complications of diabetes, which is related to its unclear pathogenesis. Rats have long been preferred in the rodent diabetes model, but advances in technology have gradually driven mice to become an important tool for the study of diabetic neuropathy. At present, there are many screening method for peripheral neuropathy in diabetic mice but no uniform standard. This paper summarizes the commonly used diabetic mouse models of diabetes and relevant method of detecting peripheral neuropathy including sensory function test, neuroelectrophysiology, pathological examinations and motor function test, aimed to provide a scientific reference for the researchers who conduct the peripheral neuropathy in diabetic mice.

Key words: Diabetic peripheral neuropathy, Sensory function test, Pathological examinations, Neuroelectrophysiology, Motor function test, Corneal observation