关键词: 横纹肌溶解综合征, 药物因素, 哈夫病

Abstract: Objective To explore the drug-induced rhabdomyolysis by coadministration of statin and fibrate in mice and rats to provide a reference for rhabdomyolysis caused by other reasons such as Haff disease. Method We administered simvastatin ( SMV) and gemfibrozil ( GF) to Wistar rats and ICR mice once daily for 14 days. The serum levels of Creatine Kinase ( CK ) , Myoglobin ( MYO ) and Alanine aminotransferase ( ALT ) , Aspartate aminotransferase ( AST) were tested before and after administration. Tissue samples from skeletal muscle were stained with hematoxylin and eosin ( HE ) and were observed under a microscope for routine pathological examination. Result The serum levels of CK, ALT and AST after SMV and GF administration to rats 10 days were prominently increased, and the muscle fiber necrosis suggested skeletal muscle-specific toxicity. Same drugs administered mice didn’ t show the increase in serum levels of biomedical parameters. Conclusion In this study, rhabdomyolysis was induced in rats by coadministration of the clinically using statin and fibrate. Wistar rats may beuseful to identify risk factors in the animal study of rhabdomyolysis such as Haff disease.

Key words: Rhabdomyolysis, drug, Haff disease