关键词: 抑郁症, 应激性动物模型, 效度

Abstract: Depression is a common mood disorders caused by a variety of reasons, with significant and lasting low mood as the main clinical features, and the low mood don’t match the situation. Some serious patients can appear suicidal thoughts and behaviors. The study of animal models of depression is the basis of the mechanism study of depression and the development of clinical drugs. Among them, stress model has become the most commonly used animal model of depression, which is widely used in basic research of depression, because the inducement that simulates depressive illness is quite sufficient and the modeling method is simple. In this paper, the main methods to evaluate stress animal models are summarized, which provides a reference for the modeling of stress depression animal models.

Key words: Depression, Stress animal model, Validity