关键词: 动脉粥样硬化 Apo E-/-小鼠, 脑栓通胶囊, 血脂水平

Abstract: To observe the effect of naoshuantong capsule on blood lipid levels in atherosclerotic mice and further explore its related mechanism of treatment on stroke. Methods Six weeks old ApoE-/- mice were fed with western diet for 12 weeks and randomly divided into three group: model group, naoshuantong low dose group and naoshuantong high dose group. The high and low dose group were given intragastric administration with 1.0 g/kg and 0.5 g/kg for 12 weeks, respectively. The model group were given normal saline of equal volume distilled water. After 12 weeks administration with naoshuantong capsule, serum was collected from the abdominal aorta for lipid levels measurement. The levels of serum lipids TC, TG, LDL-C and HDL-C were detected by enzyme method. Results Compared with model group, Naoshuantong capsule low group and high group both could decrease the levels of TC, TG, LDL-C significantly, but there was no influence on HDL-C. Conclusion Naoshuantong capsule could regulate the level of blood lipid, and its mechanism of treating stroke may be related to this pathway.

Key words: atherosclerosis, ApoE-/- mice, naoshuantong capsule, blood lipid level