关键词: 腰椎间盘突出症, 退化, COX, PGE2

Abstract: Objective To study the effect of cyclooxygenase inhibitor Fenbid on lumbar disc herniation.Method Rats were modeled by oppressing the dorsal root ganglion and transplanting the autologous tail nucleus pulposus to the lumbar spine.The COX inhibitor Fenbid was administered at a dose of 0.051 g/kg for 28 days.Animals were scored for motor function,mechanical stimulation retraction tests,animal thigh circumference measurements,and gait measurements.After 28 days of dosing,lumbar vertebrae (L4-L6)and their nerves were fixed with 10% neutral formalin and histopathological examinations were performed.The serum and nerve root tissue under pressure were measured for inflammatory factor concentrations.Result The COX inhibitor,Fenbid,can improve the animals' motor function score,50% mechanical paw withdrawal threshold,thigh circumference ratio,sciatic nerve function index (SFI),the pathological changes of dorsal root ganglion and intervertebral disc,reduce the levels of inflammatory factors (PGE2,COX-2,NO,IL-1β,IL-6)at the serum and lesion sites.Conclusion COX inhibitors improve the symptoms of lumbar disc herniation in rats.

Key words: Lumbar disc herniation, degenerationCy, clooxygenase, Prstaglandin E2