关键词: 干扰素, 内皮抑素, 融合蛋白, 抗肿瘤

Abstract: Objective To investigate the antitumor effect of I30 peptide, and to provide experimental result for the further development of I30 peptide. Method Using NIH mouse, 4 mice were injected intraperitoneally with H22 tumor strain, and all mice were sacrificed at 1 week, and ascites was extracted. Another 40 mice were injected with 0.2 mL ascitic fluid, and the cell concentration was 1×106个/mL. At 4 h after inoculation mice were treated in different groups. The mice were divided into 4 groups randomly, IFN group, subcutaneous injection of interferon 9×105 IU/mL; I30 high dose group, subcutaneous injection of 80 μg/I30; I30 low dose group, subcutaneous injection of 30 μg/I30; negative control group, subcutaneous injection of normal saline. Mice were continuous administrated for 16 d. After 2 h, all animals were sacrificed, and the subcutaneous tumor mass was dissected. Result The treatment group had obvious therapeutic effect, and the difference was significant (P<0.05). Conclusion I30 has anti-tumor effect.

Key words: Interferon, Endothelial peptide, Fusion protein, anti-tumor