关键词: 动物模型, 比格犬, 呼吸麻醉, 深静脉穿刺置管, 血液灌流

Abstract: Objective To establish an animal model through DVPC in beagles and to discuss its field of application. Method Eight adult beagles were randomly divided into the group of femoral vein catheterization (FVC) and the group of jugular vein catheterization (JVC), each group with four beagles. After anesthesia with a mixture of 1.5%-3% (v/v) isoflurane and oxygen, the beagles were fixed with a supine position in the operating table.The femoral vein and jugular were positioned to carry out DVPC and the catheters were fastened. Result DVPC for eight beagles was successful and the anesthetic effect was good. Compared with JVC, FVC operates more conveniently with shorter operating time, easier nursing and fewer complications. Conclusion The establishment of DVPC in beagles makes it possible for the application of blood perfusion and purification to laboratory animals. Meanwhile, it facilitates relevant clinical basic research. It can also be applied by vets to poisoned dogs for blood perfusion or purification and also to shock dogs for quick and mass fluid infusion.

Key words: animal model, Beagles, respiratory anesthesia, DCPC, blood perfusion