关键词: BALB/c小鼠, 突变卷毛小鼠, 血液免疫学指标

Abstract: Objective To investigate whether there is a mutation difference between the immunological indexes of BALB/c mutant mice and the normal BALB/c mice.Method Six weeks old BALB/c mutant curly and normal BALB/c mice each 20 (male and female) were selected respectively．Then 6 blood routine indexes were detected using automatic blood cell analyzer；4 antibody and complement indexes were detected using automatic biochemical analyzer；and the ELISA was used to detect serum cytokines TNF-α、 IL-2、IL-4；the result of the two groups were compared.Result The female and group result of NE、NE#、MO、and IL-4 between BALB/c mutant curly mice and normal mice have significant differences(P<0.05，P<0.01)； the male and group result of IgG and C3 between BALB/c mutant curly mice and normal mice have significant differences(P<0.01)；the sex and group result of IgM between BALB/c mutant curly mice and normal mice have significant differences (P<0.05，P<0.01)；the female result of LY between BALB/c mutant curly mice and normal mice have significant differences(P<0.05)．Conclusion There are differences in immunological parameters between BALB/c mutant curly mice and normal BALB/c mice，suggesting that the mutant gene may have a certain effect on the immune system of mice．

Key words: BALB/c mice, Mutant curly mice, blood immunological index