关键词: 高能脉冲氙光, 视功能, 防护方法

Abstract: Object To evaluate the protection method induced by high-energy xenon light on oclular tissue. Method Sixty SD rats were randomly divided into six groups: positive control group; surgical drapes group; thin white plastic sheet group; thin brown plastic sheet group; thick brown plastic sheet group and negative control group (n=10). The rats were fixed in special fixation-machine and irradiated by high-energy xenon light for 5 min (5 d, twice/d). Fissure lamps, full-field retinal electrography (ffERG), coherent optical tomography (OCT), fundus photograph and pathological examination (HE staining) were used to evaluate ocular tissue damage. Result The staining score of corneal fluorescein sodium in positive control group and surgical drapes group were greater than that of the control group (P<0.05). The amplification of b wave (dark-adaptation 3.0 and light-adaptation 3.0 response) in positive control group and surgical draping group were significantly decreasing than the negative control group (P<0.05) and the peak-time of b wave were increasing than the negative control group (P<0.05). The amplification of ∑OPs1-4wave in positive control group and surgical draping group were decreasing than the negative control group (P<0.05). OCT found that the thickness of outer nuclear layer (ONL) in positive control group and surgical draping group were thinner than the negative control group (P<0.05), which was accordance with HE staining result . There was no obvious abnormality observed with fundus photograph in each group. Conclusion Surgical drapes group, thin white plastic sheet group, thin brown plastic sheet group and thick brown plastic sheet group have a certain protective effect on high-energy xenon light and surgical drapes group is weak.

Key words: high-energy xenon light, visual function, protection method