关键词: 氯胺酮, 戊巴比妥, 丙泊酚, 山羊, 骨缺损, 椎体

Abstract: Objective To investigate the effective and safety of ketamine combined with pentobarbital sodium and propofol in the preparation of goat vertebral bone defect model Methods A total of 18 Hainan native goats were included in the study, anesthesia induction by intramuscular injection of ketamine, then maintain anesthesia by the use of ketamine combined with propofol and pentobarbital sodium. The animal model was fulfilled until lumbar verterbral body bone defect were made and filled with bone cement. The anesthesia and surgical effects, vital signs and adverse reactions were recorded. Results All surgery was successfully accomplished, the excellent and good rate of anesthesia was 100%. No animal death, and no bloating, vomiting and other adverse reactions. The duration of anesthesia induction, anesthesia and recovery period were 15.94 ± 1.76, 121.11 ± 9.44, 42.44 ± 6.73 min respectively. There was no significant difference in oxygen saturation, body temperature and respiratory rate between the several periods (P> 0.05). The heart rate during anesthesia was significantly lower than that before anesthesia, induction and recovery (P <0.05). Conclusion Anesthesia by ketamine combined with pentobarbital sodium and propofol is satisfied both its depth and effective process. This anesthesia manner meet need of preparation of goat vertebral bone defect model, also have some advantages, such as fast wake up time, long animal survival, and does not affect physiological function of animals.

Key words: Ketamine, PentobarbitalPropofol, goat , bone defect , vertebral