实验动物科学 ›› 2017, Vol. 34 ›› Issue (05): 48-52.

• 研究 论著 • 上一篇    下一篇

不同周龄 SHR、Wistar 大鼠血压及心电图背景数据的建立

  

  1. ( 1. 中国医学科学院北京协和医学院药物研究所,北京 100050) ( 2. 北京协和建昊医药技术开发有限责任公司,北京 100176)
  • 出版日期:2017-10-31 发布日期:2017-11-17
  • 基金资助:

    <p>基金项目: 国家重大新药创制资助项目( No. 2013ZX09302302,No. 2012ZX09301002 - 001 - 009)</p>

Background Data of Blood Pressure and Electrocardiograms on SHR and Wistar Rats at Different Weeks of Age

  • Online:2017-10-31 Published:2017-11-17

摘要: 摘要: 目的 建立不同周龄 SHR、Wistar 大鼠血压及心电图背景数据参考值。方法 分别选用 12 只 SHR、Wistar 大鼠,从 6 周龄开始对其体质量、血压及心电图各指标进行了为期 17 周的连续监测。结果 SHR 大鼠 6 周龄开始,体质量增长缓于 Wistar; 血压指标包括心率、收缩压、舒张压、平均压均高于 Wistar 大鼠,并从 10 周龄开始血压趋于稳定; 心电图指标,SHR、Wistar 大鼠除部分间期如 QT 间期、ST 间期指标 6 到 9 周龄数据偏低,其余指标均较稳定,其中 RR 间期、QT 间期指标,SHR 大鼠有高于 Wistar 大鼠的趋势。结论 初步建立了 6 到 22 周龄的 SHR、Wistar 大鼠心血管系统的背景数据参考值,为其进一步应用提供了参考。

关键词: <, p>, 自发性高血压大鼠, Wistar 大鼠, 血压, 心电图 <, /p>

Abstract: Abstract: Objective To set up background data reference values of blood pressure and electrocardiogram( ECG) in SHR、Wistar rats at different weeks of age. Method The values of body weight、blood pressure and ECG were obtained from 12 SHR and 12 Wistar rats since they were at 6 weeks of age to 22 weeks of age. Result The body weights of SHR had been lower than Wistar since 6 weeks of age; heart rate,systolic blood pressure,diastolic blood pressure and mean pressure of SHR were all higher than those indexes of Wistar rats,blood pressure became steady since 10 weeks; ECG indexes had been stable with the exception of QT interval and ST interval which were a little lower from 6 to 9 weeks; among these indexes,RR interval、QT interval、ST interval of SHR were higher compared with those of Wistar. Conclusion Background data reference of SHR and Wistar from 6 weeks to 22 weeks had been initially established,concluding body weight,blood pressure and ECGs.

Key words: <p>SHR, Wistar, blood pressure, electrocardiograms</p>

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