关键词: <, p>, 基因编辑, 人类疾病动物模型<, /p>

Abstract: Abstract: Gene editing is a new technology aiming at genome targeted modification，which mainly modifies target genome for the purpose of studying the gene with unknown functions and conducting gene therapy． Ｒecently，the grown-up of new gene editing techniques including engineered nuclease mediated zinc-finger nucleases( ZFNs) ， transcription activator-like effector nucleases ( TALENs) and clustered regularly interspaced short palindromic repeat sequences ( CＲISPＲ) － CＲISPＲ-associated( Cas) ＲNA-guided nuclease( CＲISPＲ Cas ＲGNs) accelerates the progress of gene function study and has an important significance in the structure of animal models of human disease and exploration of new disease treatment program． Gene editing techniques and those application in research of animal model of human disease were briefed in this paper．

Key words: <p>gene editing, animal model of human disease</p>