关键词: <, p>, FGF21, 糖尿病心肌病, 心肌纤维化<, /p>

Abstract: Abstract: Objective To investigate the effects of FGF21 on myocardial fibrosis in type 1 diabetic mice induced by STZ． Method Thirty-two 8 weeks old male C57 /BL6J mice were randomly divided into four groups，ten mice received STZ treatment，ten mice received STZ and FGF21siＲNA treatment， six mice were treated with FGF21siＲNA，and another six mice remain untreated． Type 1 diabetes was induced by STZ in concentration of 150mg / kg． Collagen fiber was observed by Masson staining and electron microscope． The expression of type 1 collagen mＲNA ( Col I mＲNA) ，type Ⅲ collagen mＲNA ( Col Ⅲ mＲNA) ，transforming grow factor β mＲNA ( TGF － β mＲNA) and FGF21mＲNA of myocardium were detected by Ｒeal-time PCＲ． Ｒesult The expression of Col I mＲNA，ColⅢ mＲNA and TGF － βmＲNA in myocardium of type 1 diabetes mice treated with FGF21siＲNA increased more than that of untreated ones，cardiac collagen fiber proliferation was worse than those of untreated ones． Conclusion FGF21 may be able to protect myocardium from fibrosis in mice with type 1 diabetes induced by STZ．

Key words: <p>FGF21, diabetic cardiomyopathy, myocardial fibrosis</p>