关键词: <, p>, 失眠, 综合评分法, 药效学, 急性毒性<, /p>

Abstract: Abstract: Objective By using pharmacodynamical and acute poison experiment，the best extraction technology was determined by comprehensive score method． Method The experimental design was to prolong the sleep time of mice with sodium hypnosis and the threshold hypnotic dose，and together with acute toxicity experiment in mice．Ｒesult NO． 7 drug could shorten substantially the sleep latent period of rats． Compared with the control group there was significant difference ( P ＜ 0. 05) ． No． 2，No． 3，No． 5，No． 7 and No． 9 groups could enhance the number of asleep mice ( P ＜ 0. 01，P ＜ 0. 01，P ＜ 0. 05，P ＜ 0. 05，P ＜ 0. 01) ; acute toxicity experiment in mice identified the LD50 of all the reagent． The results showed that the combined score of NO． 7 drugs was the highest． Conclusion NO． 7 group extraction technology was the best．

Key words: <p>insomnia, comprehensive score method, pharmacodynamics, acute toxicity</p>