关键词: <, p>, 姜黄素, 沙漠干热环境, 中暑, 大鼠, 生化指标, 生命体征<, /p>

Abstract: Abstract: Objective To study the effects of Curcumin on vital signs and related blood indexes of heatstroke rats in dry-heat environment of desert， so as to elucidated the possible mechanisms of the protective effects of Curcumin．Method The 200 male SPF grade SD rats，6 ～ 8 week-old，were randomly divided into control group，solvent group，low-dose Curcumin pretreated group，middle-dose Curcumin pretreated group and high-dose Curcumin pretreated group，40 rats for each group． Each group were intragastrically administrated for 7 consecutive days．Then all the rats were put into the dry heat environment ( temperature of 41℃，humidity 10%) in The Simulated Climate Cabin for Special Environment of Northwest of China． Each group were randomly selected 10 rats to measure core body temperature and weight at the time of 0 min，50 min，100 min，and 150 min． At each time point，the rats of were caught out of the cabin and then were be anesthezied，and arterial and venous blood were collected to detect blood gas， blood routines and biochemical indicators． Ｒesult The average core body temperature rising rate of each 10 min were significantly lower in the Curcumin high dose pretreatment group compared with the control group and the solvent group，was significantly different ( P ＜ 0． 05) ． The average weight falling rate of each 10 min were were significantly slower in the Curcumin high dose pretreatment group compared with the control group and the solvent group ( P ＜ 0． 05) ． The average weight falling rate of each 10 min in the high-dose Curcumin pretreated group was negatively correlated with pO2 ，pH，Glucose and Triglyceride ( r =－ 0. 955、－ 0． 355，－ 0． 692，－ 0． 733) ，and positively correlated with the number of white blood cells ( r = 0. 943) ． Conclusion The average weight falling rate and the average core body temperature rising rate may be the useful indicator for the prognosis of the heatstroke rats; Curcumin may maintain higher level of blood pO2，blood glucose and triglyceride，slow down the falling speed of blood pH，and decrease the blood leucocyte numbers through reducing the average weight falling rate and the average core body temperature rising rate of heatstroke rats in dry heat environment of desert，hence maintain good internal environment，so as to exerted its protective effects on the heatstroke rats in the dry heat environment of desert．

Key words: <p>Curcumin, dry heat environment of desert, rats, biochemical indicators, vital signs</p>