关键词: <, p>, 化妆品, 动物试验法, 安全毒理学, 状况调查<, /p>

Abstract: Abstract: Objective By sampling for cosmetics sold in some cities in Hebei，the situation of safety toxicological of the cosmetics was investigated． Method Using the animal experiments method，the 33 cosmetics were tested on toxicology． The cosmetic samples collected from markets，they were the beauty cream，sunscreen，facial cleanser and body wash and so on． Ｒesult Nineteen cosmetics ( 8 of body wash，8 of facial cleanser and 3 of beauty cream) in rabbits acute skin irritation test that resulted for non-irritating 10 cases ( 52. 6%) ，9 cases of mild irritant ( 47. 4%) ; 16 samples ( 8 of body wash and 8 of facial cleanser) in rabbits eye irritation test resulted for 0 cases of non-irritating reaction，micro stimulation 3 cases ( 18. 8%) ，13 cases of mild stimulation ( 81. 2%) ; The results of 17 samples ( 3 of beauty cream，9 of Sunscreens and 5 of Freckle cream) in the guinea pig skin allergy tests displayed that the weakly and mild allergenic reaction were total of 3 cases ( 17. 6%) ，and no allergic reactions in 14 cases ( 82. 4 %) ． Conclusion Survey results show that all kinds of cosmetics have different proportions of light ( or micro) of the toxicological response． Although it can be determined that the products under investigation are acceptable for the human，but suggested that the regulatory authorities should attach importance to and strengthen risk monitoring，in order to protect the safety of consumers．

Key words: <p>cosmetics, animal test methods, safety toxicology, investigation</p>