关键词: <, p>, 姜黄素, 沙漠干热环境, 中暑, 电解质<, /p>

Abstract: Abstract: Objective To observe the effect of Curcumin pretreatment on serum and urine electrolytes in desert environment heat stroke rats． Method One hundred and forty male SD rats，200 ～ 250 g，were randomly divided into two groups: heat stroke group at 0h and heat stroke group after 24 h，each groups were made of seven subgroups，with 10 rats in each subgroup: normal sodium chloride control group，mild heat stroke sodium chloride group，moderate heat stroke sodium chloride group and severe heat stroke sodium chloride group，mild heat stroke Curcumin group，moderate heat stroke Curcumin group and severe heat stroke Curcumin group． The conditions of normal temperature group were at 25 ℃，humidity 35% ＲH，the condition of heat stroke group were 41 ℃，humidity 10%ＲH． A number of rats in the heat stroke zero hour were collected the inferior vena cava blood for serum electrolyte determination，another group of rats were collected the urine and inferior vena cava blood 24 hours after heat stroke． The serum and urine electrolyte was measured． Ｒesult With the deepening of the heat stroke，serum K + gradually decreased，Na + ，Cl － ，Ca2 + had an increasing trend，but did not reach a significant level，after Curcumin intervention，serum K + was retain to normal gradually ，while serum Cl － ，Ca2 + ，Na + were significantly increased． 24 h after heat stroke，serum K + in mild and moderate heat stroke groups returned to normal levels，while in severe heat stroke group，serum K + concentration was still very low． After Curcumin intervention，the serum K + level of the mild and moderate heat stroke rats increased significantly，and was significantly higher than that of the normal level，while the serum K + of the severe heat stroke rats recovered to normal level． And Na + ，Cl － ，Ca2 + ，24 h after heat stroke ，were restored to normal levels． As well as Curcumin was concerned，the concentrations of K+ ，Na + ，Cl-were lower in urine 24 h after heat stroke，and urine Cl-was increased significantly． Conclusion Curcumin can enhance serum K + concentration and promote urine Cldischarge to correct heat stroke rats electrolyte disturbances in heat-dry desert environment．

Key words: <p>Curcumin, desert environment, heat stroke, electrolyte</p>