关键词: <, p>, 肿瘤, PDX, 小鼠模型<, /p>

Abstract: Abstract: Patient-derived tumor xenograft ( PDX) mouse models have been used for nearly half a century，and have been one of the important tools in the area of oncology study． In contrast to the traditional tumor-bearing mouse models，PDX mouse models were demonstrated to keep the characteristics of genome，transcriptome，proteome and aberrant signal pathways of real-world patient tumors to the largest extent in vivo，rendering them ideal Avatar substitutes of tumor patients to be extensively used for personal drug testing． Ｒecently，with the development of the concept of tumor precision medicine，the requirement and utility of PDX mouse models are gradually increased，especially for screening and evaluating the effective anti-tumor drugs on the basis of PDX mouse models．Furthermore，it is on the way from bench to bed in the clinic to direct the personal therapy for tumor patients according to the drug screening results from PDX mouse models． Herein，this paper will summarize the critical factors in successful generation，the clinical applications and potential limitations of PDX mouse models．

Key words: <p>tumor, PDX, mouse models</p>