关键词: 谷氨酰胺, 鸭, 鸭瘟, 十二指肠, TLR4 通路

Abstract: Abstract: Objective To investigate the effect of Glutamine ( Gln) on the intestine physiological activity and the pathway in normal ducks and the models infected with the plague virus． Method 280 specific pathogen free ( SPF) ducklings were randomly divided into eight groups． Gln was administrated at different doses ( 0，0. 5，1，2 g / kg / feed / d) by oral gavage to the control groups and the model groups infected with 0. 2 mL duck plague virus ( DPV)( 0. 2 mL 2000TCID50) ，respectively． The procedures were performed for 6 days． Effects of Gln in control and model ducklings were detected，and expression of the Toll like receptor 4 ( TLＲ4) pathway genes were determined．Ｒesult Expression of TLＲ4 pathway mＲNAs was increased significantly in normal group ( P ＜ 0. 05) ，but reduced significantly in the model groups ( P ＜ 0. 05) ． Conclusion Gln improves immunity in duckling intestine through the TLＲ4 pathway，and resists the immune-mediated injury caused by DPV．

Key words: glutamine, duck, duck plague virus, duodenum, TLR4 pathway