实验动物科学 ›› 2015, Vol. 32 ›› Issue (01): 59-60.

• 研究 论著 • 上一篇    

通过调节免疫系统功能治疗癌症

  

  1. (中国农业大学 国家动物海绵状脑病实验室,北京 100093)
  • 出版日期:2015-02-28 发布日期:2016-12-07
  • 基金资助:

    国家科技支撑计划 十二五(NO. 2011BAI15B01,2012. 1 - 2016. 12)

Treating Cancer by Regulating the Immune System

  • Online:2015-02-28 Published:2016-12-07

摘要: 摘要: 目前,对癌症的治疗除采取手术和化疗方法外,还没有发现可靠的治疗方法。科学研究表明,CTLA-4 和 PD-1是体内的两种蛋白,他们能抑制免疫系统发挥免疫攻击能力,从而导致肿瘤的形成。通过针对这两种蛋白制 备的单克隆抗体,可以破坏他们的抑制作用从而激活免疫系统,发挥抗肿瘤生长作用。此外,通过对 T 细胞进行基 因修饰可以使其将肿瘤细胞作为靶细胞。这种免疫疗法可被用于癌症的治疗并且已经取得了初步的成功。本文对以上两种方法的基本情况作了简要论述。为该领域的研究实践提供一定的参考。

关键词: 癌症, 治疗, 单克隆抗体

Abstract: Abstract:Currently,except surgical treatment,we have not found a reliable method of treatment. CTLA - 4 and PD - 1 are two kinds of protein which are produced by T cells. They can puts the brakes on T cells,preventing them from launching full-out immune attacks. By using the monoclonal antibodies of these two protein,the blockerthe CTLA - 4 molecule can be blocked and set the immune system free to destroy cancer. In addition,a personalized treatment that involves genetically modifying a patient’s T cells can make them target tumor cells. It can be used in cancer treatment and is very potential. In this article will make a brief discuss of the above two methods and provide a reference of research in this yield.

Key words: cancer, treatment, monoclonal antibody

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