关键词: 硝酸银, 耐药性, 抑菌, 创伤动物模型

Abstract: Abstract: Objective To investigate whether silver nitrate has the advantages over conventional antibiotics in the therapy effect of wound infected with S．aureus and P．aeruginosa in mice． Method The research was divided into three groups． Firstly animal models of trauma was established，and the wound surface was infected with S．aureus ， P．aeruginosa and mixed infected with the two bacteria，respectively． Then each group was treated with different concentration of silver nitrate． Finally，scab and healing time were recorded and analyzed． Result To the bacterial infection of wound surface，silver nitrate played the same therapeutic effect with antibiotics，and was also effective for the treatment of drug resistance of P．aeruginosa． Conclusion In this study，we confirm the bactericidal effect and wide antimicrobial properties of silver nitrate in vivo． With the bactericidal and bacteriostatic effects of the silver particles and silver ions are re-realized in the modern medicine，the combination of silver nitrate and antibiotics may be an effective therapy strategy in clinical．

Key words: silver nitrate, drug resistance, antibacterial effect, trauma animal model