关键词: 硝酸银, 耐药性, 抑菌作用, 抗生素

Abstract: Abstract: Objective To investigate whether the silver nitrate has the advantages over conventional antibiotics in sterilization of common bacteria and fungi． Method Plate dilution method was performed，that is，three drugs were dissolved in the culture medium at different concentrations，and then the bacteria and fungi were plated． The minimum inhibitory concentration was determined by growth situation of the bacteria and fungi． Result Silver nitrate had similar inhibitory function to both bacteria and fungi ( P ＞ 0. 05 ) and the minimum inhibitory concentration was between 3 － 7 μg /mL． For antibiotics，the minimum inhibitory concentration of neomycin to S． aureus and K． pneumoniae was between 0.1 － 1.0 μg /mL and that of gentamicin to S．aureus and E．coli were 0.1 μg /mL and 1.25 μg /mL，respectively． However，there was no inhibitory function was found for gentamicin against P．aeruginosa，and the inhibitory function of neomycin against P．aeruginosa was 16 μg /mL． Conclusion There is no selectivity of inhibitory effect for silver nitrate against bacteria and fungi． Comparatively，the antibiotics prefer to inhibit the bacteria，but not fungi． With the bactericidal and bacteriostatic effects of the silver particles and silver ions are re-realized in the modern medicine，the combination of silver nitrate and antibiotics may be an effective therapy strategy in clinical．

Key words: silver nitrate, drug resistance, antibacterial effect, antibiotics