关键词: 黄柏煎剂, 抗炎, 抗菌

Abstract: Abstract: Objective To observe the anti-inflammatory and antibacteria effect of Cortex Phellodendri Chinensis decoction( CPCD) ． Method 50 Kunming mice were randomly divided into 5 groups，The mice in the study groups were administered intragastrically with CPCD，the outer ears of all mice were inflamed in left as experimental group and the right ears were not treated as a control group after treated 7 days，and then，each ear of all mice were calculated the swelling and suppression mice; 40 SPF SD rats in the left and right forelimbs were made granulomas， and then all rats were randomly divided into five groups based on the weight，and the rats were administered intragastrically with CPCD within 7 days，then，the weight of each group granulomas were calculated; 60 Kunming mice were randomly divided into six groups according to sex and body weight，all groups mice were administered intragastrically with CPCD within 7 days according to the corresponding dose，and then，each group were administered with intraperitoneal injection of Staphylococcus aureus bacteria in the first seven days of administered after 1 h，in the first seven days of administered 6 h the mice were administered once more，mortality of mice was observed in 72 hrs． Result Experimental groups were compared with control groups，each dose group which was administered intragastrically with CPCD could inhibit ears swelling of mice in different levels，the difference was statistically significant ( P ＜ 0. 05 or P ＜ 0. 01) ，of which the best group was low-dose group; Experimental groups were compared with the control group，low-dose groups which was administered intragastrically with CPCD could significantly reduce the weights of rat granulomas ( P ＜ 0. 05) ，and high dose group and medium dose group could not significantly reduce the weights of rat granulomas which were compared with the control group，the differences were not statistically significant ( P ＞ 0. 05 ) ; The mice were treats with high，medium and low-dose groups，the mortality of mice were 50% ，40% ，20% ，which were compared with the control group，the low-dose group can reduce the mortality of the mice ( P ＜ 0. 05 or P ＜ 0. 01 ) ． Conclusion CPCD had anti-inflammatory and antibacteria effect．

Key words: Cortex Phellodendri Chinensis decoction, anti-inflammatory, antibacteria