关键词: db /db 鼠, 成模率, 糖尿病视网膜病变, 闪光视网膜电图

Abstract: Abstract: Objective To observe the model of diabetic retinopathy(DR) on db /db mice． Method During the seven months，the mice were weighted and the caudal vein was taken to test fast blood glucose once a month． Seven months later，F-ERG was examined on ten db /db mice and six db /m mice ( normal control group). Result The body weight of db /db mice rised obviously，while the fast blood glucose rised unremarkably． 97% db /db mice were under the standard of the fast blood glucose of the model of DR mice( 11. 1 mmol /l). The statistical result of F-ERG showed that the latencies of a-wave and b-wave were delayed significantly in the experimental group( P <0. 01), and the amplitude of b-wave was significant lower in the experimental group( P < 0. 01), compared with normal control group. There were significant difference( P < 0. 01) in the total amplitude of Ops and O2 between normal control group and experimental group． Conclusion Although most of their fast blood glucose are under the standard in this experiment，the retina of db /db mice have changed as the early lesion of DR． So the standard of the model should consider the change of the retina，instead of just depend on fast blood glucose． The standard of model by db /db mice should be modified，through more researches are needed．

Key words: db /db mice, the success rate of modeling, diabetic retinopathy, F-ERG