关键词: 氟中毒, 基础生长, 拮抗作用

Abstract: Abstract: Objective To study the effects of chronic fluorosis on the growth of rate and the antagonism of Mg2 + ， Al3 + and Ca2 + to fluorine toxicity so as to provide the data for the researches on the molecular mechanism and the treatment of endemic fluorosis． Method 24 the first week postweaning male SD rats were randomly divided into 4 groups ( n = 6 in each group) ，namely the control group ( group 1) ，fluoridating group ( group 2) ，fluorine + Mg2 + + Al3 + group ( group 3) and fluorine + Ca2 + group ( group 4) ． The water added with fluorine，with fluorine + Mg2 + + Al3 + and with fluorine + Ca2 + was respectively given to the rats in the different groups for three months． The body weight，food intake and the amount of water drinking were measured and recorded every two days，and the 24 － hour urine was collected daily to determine the fluorine content in the urine during 3 days before sacrifice． Result The speed of weight gain in group 4 was significantly higher than that in group 1，and the speed of weight gain in group 2 and group 3 was significantly lower than that in group 1． Urine fluorine content of group 2 was higher than that of the other 3 groups，while that of group 3 and group 4 was lower than group 2 but higher than group 1． There was no significant difference in food intake and amount of water drinking among groups． Conclusion The chronic fluorosis could decelerate the growth rate，while adding Mg2 + ，Al3 + or Ca2 + into the drinking water，especially Ca2 + ，may antagonize this effect．

Key words: chronic fluorosis, growth, antagonistic effects