关键词: 长爪沙鼠, 高脂血症, 脂肪肝

Abstract: Abstract: Objective To Compare four methods of developing hyperlipidemia in Mongolian gerbils． Method The gerbils in the experimental groups were fed respectively with four high-fat fodders with varying amounts of cholesterol，lard and cholate． The gerbils in the control group were fed with normal fodder． Serum levels of triglyceride ( TG ) ，total cholesterol ( TC ) ， low-density lipoprotein cholesterol ( LDL-C ) and high-density lipoprotein cholesterol ( HDL-C) in the gerbils in all the groups were measured at the 0th，30th，60th day． Animals were sacrificed and the morphological changes of the liver were examined by histopathology． Result Serum levels of TC，LDL-C and HDL-C in gerbils of the experimental group were significantly higher than those in gerbils of the control group during the 30th，6 0th days，with a remarkable increase in serum TC level in particular， and increase of serum LDL-C were obviously bigger than the increase of serum HDL-C． There have been varying degrees of fatty liver in the experimental groups． Conclusion Four high-fat fodders can all cause hyperlipidemia in the gerbils．

Key words: Mongolian gerbil, hyperlipidemia, fatty liver