快速老化小鼠SAM-P /8 出现类帕金森病现象初探

实验动物科学 ›› 2012, Vol. 29 ›› Issue (01): 6-8.

快速老化小鼠SAM-P /8 出现类帕金森病现象初探

( 1．天津中医药大学第一附属医院韩景献全国名老中医药专家传承工作室，天津300193) ( 2．天津中医药大学，
天津300193) ( 3．宁夏医科大学基础医学院人体解剖与组织胚胎学教研室，银川750004)

出版日期:2012-02-29 发布日期:2014-04-16
基金资助:
国家自然科学青年基金( No． 30901927) ; 教育部新世纪优秀人才计划( No． NCET-07-0616 ) ; 高等学校博士学科点专项科研基金( No． 20101210110005) ; 天津市应用基础及前沿技术研究计划( No． 09JCYBJC12600)

Senescence Accelerated Mouse SAM-P /8 Appears Syndrome Similar to Parkinsons Disease

Online:2012-02-29 Published:2014-04-16

摘要/Abstract

摘要： 摘要: 目的探讨快速老化小鼠SAM-P /8 的同向旋转现象与帕金森病动物模型的相关性。方法取发作旋转行为的7 月龄雄性SAM-P /8 和同源对照SAM-R /1 小鼠各6 只，分为旋转组和正常对照组两组，首先采用老化度评价标准对其老化度进行评定，其次根据帕金森病动物模型造模标准对其旋转行为进行评定。结果同月龄SAM-P /8 的老化度高于SAM-R /1; SAM-P /8 出现可重复的同向右侧旋转，频率为60 r /min，符合帕金森病动物模型造模成功的标准，SAM-R /1 无旋转现象出现。结论初步认定SAM-P /8 的同向旋转现象为类帕金森病现象，对帕金森病研究有重要意义。

关键词: SAM-P /8 小鼠, 同向旋转, 帕金森病

Abstract: Abstract: Objective To explore the relativity between the rotational behavior of Parkinsons disease mice model and the spontaneous rotational behavior to the same direction in senescence accelerated mouse SAM-P /8． MethodsThe mice were divided into 2 groups : 1． Rotation group includes 6 Male SAM-P /8 at 7-month old that appear rotational behaviors2． Normal control group includes 6 Male SAM-R /1 at 7-month ． First applies “the scores of aging”to study the aging symptoms; then evaluate their characteristics of behavior of rotation to the same direction by PD mice model standard． Results Compared with SAM-R /1 control group，SAM-P /8 group appeared obvious aging sign and symptoms at 7 months old; SAM-P /8 appear steady rotational behavior to the same direction，the frequency is 60 rotations per minute． This kind of rotation behavior coincides with PD mice model standard． Conclusions Senescence accelerated mouse SAM-P /8 appears syndrome similar to PD． This discovery will make sense to the research of PD．

Key words: mouse, SAM-P /8, rotation to the same direction, Parkinson

刘云鹤, 苗珍花, 李震, 成海燕, 曲由, 刘阿庆, 许文斌, 温明菲, 尚磊, 陈璐, 韩景献, 于建春. 快速老化小鼠SAM-P /8 出现类帕金森病现象初探[J]. 实验动物科学, 2012, 29(01): 6-8.

LIU Yun-He, MIAO Zhen-Hua, LI Zhen, CHENG Hai-Yan, QU You, LIU A-Qing, XU Wen-Bin, WEN Ming-Fei, SHANG Lei, CHEN Lu, HAN Jing-Xian, YU Jian-Chun. Senescence Accelerated Mouse SAM-P /8 Appears Syndrome Similar to Parkinsons Disease[J]. laboratory animal science, 2012, 29(01): 6-8.

[1]	马任驰，罗斌斌，岳峰. 帕金森病食蟹猴系统性模型构建与在体临床过程的动态评价研究[J]. 实验动物科学, 2019, 36(02): 9-.
[2]	王笛,于小平, 王维. 制备偏侧帕金森病猴模型的术前准备及术后护理[J]. 实验动物科学, 2014, 31(03): 50-52.
[3]	朱少平, 胡利, 鲍波. 乳胞素诱导帕金森病大鼠模型行为学及病理学观察[J]. 实验动物科学, 2013, 30(04): 26-30.
[4]	郭德玉;于向东;陈彪;田欣;祝自新;李斌;王钜;. MPTP致C57BL/6小鼠帕金森病模型的复制及常用的行为学分析方法[J]. 实验动物科学, 2010, 27(02): 1-4.