关键词: 小鼠, 大鼠垫料, 体质量, 血生化, 脏器系数

Abstract: Abstract: Objective To investigate the effects of bedding materials from poplar，corn and pine on the body weight，the blood biochemical parameters，the organ weights and coefficients of mice and rats． Methods The 60KM mice were divided into three groups randomly，20 in every group，half male and half female，used the bedding materials from poplar，corn and pine respectively． The 60 Wistar rats were divided into three groups randomly，20 in every group，half male and half female，using bedding materials from poplar，corn and pine respectively． The body weight were Weighed weekly，the blood biochemical parameters，including ALT，TP，ALP，LDH，T-SOD，ADH，were measured，a nd the organ weight were weighed after 4 weeks，then organ coefficients were calculated． Results 1. The body weight: Comparing with animals used poplar bedding，the weight of the male mice used pine bedding is reduced，P ＜ 0. 001． Comparing with animals used corn bedding，the weight of the male rats used pine bedding is reduced from third week，P ＜ 0. 05． 2. The blood biochemical parameters: mice: Comparing with the mice used poplar bedding，ALT of male mice used corn bedding is raised very significantly，P ＜ 0. 001; LDH of female mice used pine bedding is reduced significantly，P ＜ 0. 01，ADH of male mice used corn and pine bedding is reduced significantly，P ＜ 0. 001，P ＜ 0. 05． rats: Comparing with the rats used poplar bedding，ADH of male rats used pine bedding is raised significantly，P ＜ 0. 01。3. Organ weights: Mice: comparing with the mice used poplar bedding，the liver and brain weight of male mice used pine bedding is reduced significantly，P ＜ 0. 01，P ＜ 0. 05; the kidney weight of male mice used pine bedding is raised，P ＜ 0. 05，and the adrenal gland weight is reduced，P ＜ 0. 05，and the testiculus weight is raised，P ＜ 0. 05． Rats: comparing with the rats used poplar and pine beddings，the liver weights of rats used corn beddings are raised significantly respectively; P ＜ 0. 001，P ＜ 0. 05; comparing with the rats used poplar beddings，t he kidney and brain weights of rats used pine beddings are raised significantly respectively， P ＜ 0. 01，P ＜ 0. 01; comparing with the rats used corn and poplar beddings，the prostate weights of rats used pine beddings are raised significantly，P ＜ 0. 01． 4. Organ coefficients: Mice: Comparing with the mice used poplar bedding，the liver and brain coefficient of male mice used pine bedding is reduced significantly，P ＜ 0. 01，P ＜ 0. 05，and the kidney and testiculus coefficient of male mice used corn and pine bedding is raised significantly，P ＜ 0. 01． Rats: Comparing with the rats used poplar bedding，t he liver coefficient of male rats used pine bedding are raised significantly，P ＜ 0. 001． Conclusion The poplar material is the ideal beddings for mice and rats，and the corn maybe a backup bedding material，but the pine bedding is prudential usage as mice and rat bedding．

Key words: mice, rat bedding material, body weight, blood biochemical parameters, organ coefficients