关键词: 心脏移植, 小鼠, 急性排斥模型

Abstract: Abstract: Objective To establish and compare of donor-recipient in BALB / c and C57BL /6 mice on acute cardiac allograft rejection model． Methods Making BALB / c and C57BL /6 mice with donor-recipient on cardiac transplantation model and assessment of the immune rejection situation and complications，the survival time was observed and cardiac allograft was harvested for histopathological evaluation． Result Success rate was 94. 7% ． A group ( BALB / c → C57BL / 6) and B group ( C57BL /6 → BALB / c) have no significant difference in survival time． Two groups have typical pathological changes of acute rejection，and have no significant statistical difference． Two groups of heart function after heart transplantation also have no significant difference． Conclusion Inbred BALB / c and C57BL /6 mice have genetically stable characteristic，different donor -recipient combinations between BALB / c and C57BL /6 inbred mice are suitable for acute rejection model． C57BL / 6 as recipient are rational choice because the transplantation time was significantly shorter and the higher the success rate in model．

Key words: heart transplantation, mice, acute rejection model