黄芪注射液对D一半乳糖所致衰老小鼠的免疫、衰老和血脂指标的影响

实验动物科学 ›› 2011, Vol. 28 ›› Issue (06): 7-9.

黄芪注射液对D一半乳糖所致衰老小鼠的免疫、衰老和血脂指标的影响

(1．辽宁何氏医学院，沈阳110163)(2．中国医科大学实验动物中心，沈阳110001)
(3．沈阳药科大学生命科学与生物制药学院，沈阳1lOOl6)(4．辽宁中医药大学，沈阳110032)

出版日期:2011-12-31 发布日期:2013-08-08

Effect of Astragalus Injection on Immune，Aging and Plasma Lipid in Aging Mice Induced by D-galactose

Online:2011-12-31 Published:2013-08-08

摘要/Abstract

摘要： 目的探讨黄芪注射液对D一半乳糖致衰老小鼠抗衰老作用。方法皮下注射D一氨基半乳糖制作衰老鼠模型，同时每日对不同组小鼠分别腹腔给予相应药物，8周后处死小鼠，观测小鼠血液中丙二醛(MDA)、超氧化物歧化酶(SOD)、总胆固醇(Tc)、甘油三酯(TG)，并测定肝脏、脾脏与胸腺的系数。结果与模型组相比，模型+黄芪组血清中SOD明显升高，MDA、TC和TG含量降低。结论黄芪注射液能提高机体抗氧化酶活性，增加免疫器官质量，有较好的抗衰老作用。

关键词: 黄芪注射液, D一半乳糖, 抗衰老

Abstract: Objective To investigat the aging effects of astragalus injection on the mice induced by D—galactose． Methods The aging model mice were established by subcutaneous injection of D—galactosamine．The mice at the different groups were intraperitoneal injected by the different drugs．After 8 weeks，the mice were killed，and the parameters of malondialdehyde(MDA)，superoxide dismutase(SOD)，triglyceride(TG)and total cholesterol(TC) were observed，and the liver index，spleen index and thymus index were determined．Results Compared with the model group，the activity of SOD obviously increased(P<0．05)in astragalus group，and the content of MDA，TG and TC obviously increased also．Conclution Astragalus injection can increase the activities of antioxidant enzyme，increase the quality of immune organs，has the nice effects on aging．

Key words: astragalus, D-galactose, aging effects

中图分类号:

R一332

吴骁, 王光, 李彦, 张秋华. 黄芪注射液对D一半乳糖所致衰老小鼠的免疫、衰老和血脂指标的影响[J]. 实验动物科学, 2011, 28(06): 7-9.

WU Xiao, WANG Guang, LI Yan, ZHANG Qiu-Hua. Effect of Astragalus Injection on Immune，Aging and Plasma Lipid in Aging Mice Induced by D-galactose[J]. laboratory animal science, 2011, 28(06): 7-9.

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