关键词: 三聚氰胺, 孕鼠, 动物模型

Abstract:  Objective The animal model of melamine on SD pregnant mice is to study the effects of melamine on pregnant mice. MethodDuring the pregnancy， melamine at concentrations of 0,120,240,360,480,600,720 mg/kg•d was fed to observe the growth of pregnant mice ,the number of offspring ,the concentrations of melamine in fetal blood and kidneys by ELISA assay, and to detect the  function and pathological changes of fetal kidney. Result The group determined as the model group is that fed at concentration of 720 mg/kg•d: the growth rate during pregnancy was decreased (P <0.05); the development of offsprings were affected (P <0.05); the concentrations of melamine in fetal blood and kidney were higher (P <0.05); the function of fetal kidney was destroyed; And significant pathological changes appeared in renal tissue. Conclusion The pregnantmice fed with melamine at concentration of 720 mg/kg•d has serious toxic effect , and the animal model of melamine on the pregnant mice was established successfully.

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