关键词: 抑郁症, 动物模型, 评价

Abstract: Objective  To establish the animal model of depressed rats and evaluate the related parameters. Methods A total of 40 adult SD rats were randomly divided into ontrol group(n=20),and model group(n=20).Using the chronic unpredictable mild stress to establish the animal model of depressed rats,.The behavior of rats was tested at each weekend．The behaviors of rats were evaluated by open-field test, and the consumption of saccharose, body weight, and the content of NE、5-HT、CORT were observed too. Results There were differences in crossing and rearing score in open-field test,the consumption of saccharose, body weight, intake,NE,5-HT,CORT between model groups and blank control groups(p<0.05orp<0.01). Conclusion Using the chronic unpredictable mild stress the animal model of depressed rats was established which accorded with the requested characteristics of depression,and could be regarded as experimental model of depression.

Key words: font-size: 10.5pt, mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体" lang="EN-US">Depression, animal model, evaluation