关键词: 肝缺血再灌注损伤, 重组人Elafin, 谷丙转氨酶(ALT), 谷草转氨酶(AST), 乳酸脱氢酶(LDH)

Abstract: Abstract： Objective To investigate the role of neutrophil elastase inhibitor(Elafin)in pathogenesis of hepatic ischemia—reperfusion injury(HIRI)．Methods The rat model of hepatic ischemia—reperfusion was administrated with Elafin at different doses，and then the levels of ALT，AST and LDH in 8ernm were measured．Meanwhile， pathohistological changes in liver were examined． Results The rats showed severe hepatocytic damage after hepatic ischemia-reperfusion and serum levels of ALT，AST and LDH were significantly raised(P<0．001)． However，those symptoms could be relieved to some extent by preoperative injection of Elafin．Conclusion Neutrophil elastase inhibitor Elafin has a protective effect against hepatic ischemia—reperfusion injury in rats．

Key words: Hepatic iscbemia-reperfusion injury, Neutrophil elastase inhibitor, ALT, AST, LDH