关键词: Wistar大鼠, NIH小鼠, 性周期, 雌二醇, 促黄体激素, 受体, FSH

Abstract: ObjectiveTo delve into the changeable regulation of sex hormones in a sexual cycle in female Wistar rats and NIH mice.Methods The different periods of a sexual cycle in female Wistar rats and NIH mice were defined by vaginal smear examination,and FSH,LH,and E_2 levels in serum at different periods of a sexual cycle were determined by radioimmunoassay.Results In female Wistar rats and NIH mice,the difference in E_2 level of serum between the different periods was not significant.LH level was the highest in Wistar rats and NIH mice of superovulation,and the difference in LH level of serum between Wistar rats and NIH mice of superovulation and those at other different periods was very significant statistically(P<0.01).FSH level was the highest in Wistar rats and NIH mice of metestrus,and the difference in FSH level of serum between the metestrus and other different periods was very significant statistically (P<0.01).Conclusion The levels of FSH,LH,and E_2 in serum of female Wistar rats and NIH mice at the different periods of a sexual cycle are regularly changeable.

Key words: Wistar rat, NIH mouse, Sexual cycle, Estradiol, Follicle-stimulating hormone(FSH), Luteotropic hormone(LH), Receptors