关键词: 慢性氟中毒, 抗氟复方当归散, 骨氟含量, 抗氧化力

Abstract: ObjectiveTo carry out comparative studies on pharmacological effects five kinds of antifluorine Chinese herbal compound powder formulated according to the theories of the modification based on flavor and action of different Chinese herbs,and establishing of therapeutic principles based on syndrome differentiation in traditional Chinese medicine.Methods All the Wistar rats were randomly divided into 7 groups,namely,5 therapeutic groups with anti-fluorine Chinese herbal compound powder,negative control group,and positive group.The rats of the negative group drank freely normal tap water and the rats of the other groups drank the water containing 100 mg fluorine per liter.Five kinds of anti-fluorine Chinese herbal compound powder were orally administered to the rats of therapeutic groups at a dose of 0.1g/kg respectively.The dental fluorosis was observed and content of fluorine in bone,malondialdehyde levels and activities of total superoxide dismutase,catalase,and glutathione peroxidase in plasma,liver,and kidney were determined when finishing of the test.Results The fluorosis was found only in the rats of positive group.The anti-fluorine Chinese herbal compound powder could obviously decrease the content of fluorine in bone,inhibit significantly the lipid peroxidation and enhance the antioxidase activity in the rats.Conclusion The anti-fluorine Chinese herbal compound powder could depress the generating of fluorosis by inhibiting the lipid peroxidation and enhancing the antioxidase activity in the rats.

Key words: Chronic fluorosis, Compound anti-fluorine Danggui powder, Fluorine content in bone, Oxidation resistance