Abstract: The development of cancer research has been promoted strongly by the creation of transgenic mice technique. Transgenic mice are the excellent models for the study of development, growth, metastasis, prevention and therapy of human malignant tumors in vivo. There are multiple genes especially oncogenes and tumor suppressor genes involved in'the genetic alterations which regulating the growth and differentiation of cells. It may be necessary to pay attention to the different expression patterns in independently produced transgenic mouse lines constructed with the same structural oncogene. Specializtion and enterprization may be important for our country to speed up the applied researche of transgenic animals in many scientific ficlds.

Key words: Transgenic mice, Cancer, Oncogene, Tumor suppressor gene

摘要： 转基因小鼠的出现有力地推动了肿瘤研究的发展。具有癌症倾向的转基因小鼠，是从DNA水平开展有关人类恶性肿瘤发生、生长、转移和防治研究的良好活休模型。肿瘤形成与控制细胞生长和分化的多种基因特别是癌基因、抑癌基因的遗传改变有关。在利用转基因小鼠进行实验研究时，对由相同结构基因建立的不同转基因小鼠家系在癌基因表达上的时空差异性，应当给予足够的重视。此外，实现转基因动物生产的专业化、产业化，将会加速我国生命科学领域中转基因动物应用研究的进程。

关键词: 转基因小鼠, 肿瘤, 癌基因, 抑癌基因