Abstract: Buffer tablets of Diclofenac sodium was used as treat groups, the enteric coated tablets as a positive control group. Water as a negative control group in the test.The results showed that buffer tablets could inhibit the swelling of toe of rats caused by carrageenin significantly (p<0.001), and its diminishing inflammation was longer than that of enteric coated tablets. The buffer tablets could also inhibit granulation of rats caused by cotton balls significantly (P<0.001.

Key words: buffer tablets of Diclofenac sodium

摘要： 以双氯灭痛肠溶片为阳性对照，水为阴性对照，观察双氯灭痛缓释片对角叉菜胶引起大鼠足爪肿的影响和对棉球引起大鼠足爪肿影响。两项药效学试验结果表明：缓释片具有显著抑制角叉菜胶引起大鼠足爪肿（P＜0．001），且与肠溶片比较，消炎作用持久。缓释片对棉球引起大鼠肉芽肿也具有显著抑制作用（P＜0．001）。

关键词: 双氯灭痛缓释片, 双氯灭痛肠溶片, 比较