Abstract: It is our aim to establish model combining disease with syndrome of chronic atrophic gastritis(CAG) in rats more corresponding to symptoms of disease,syndrome and combining disease with syndrome in clinic.Design of methods how to establish the model:①To establish the model for a long time:We believe that “chronic” is not only simply a character of the disease,but a concept of dimension.It send the pathology of disease to three dimensions.Therefore we selected a fairly long time to establish all models of disease,syndrome and combining disease with syndrome in rats.Results have revealed that there were not hemorrhage,ulcer and dissipated in all gastric mucosa membrane of models,and exudation,necrosis is not the major pathology change in tissues of models.②Establishing the model of CAG:We considered that the precancerous lesion,even the carcinomatous change is only the result and termination of deficiency syndrome.Carcinogen is the especial matter of to cause deficiency syndrome.We did not use carcinogen to cause CAG,but general modeling factors as far as possible.We also pay attention to the change of entire body related to CAG as to estimated the model of combining disease with syndrome of CAG.③Establishing the models of syndrome:Methods of establishing the deficiency syndrome of spleen,stagnation syndrome of the liver,deficiency syndrome of the kidney are developed.According to the request of this experiment and the results of pretestings,we prolong the time to make model.④Establish the model of combining disease with syndrome:Deficiency syndrome of kidney was not taken as the major syndrome of CAG in clinic.According to reverse recapitulation law,we believe that the essence of CAG,especial precancerous lesion of gastric mucosa membrane,is deficiency syndrome of kidney.As far as possible we also pay more attention to integrating the modeling factors of disease with the modeling factors of syndrome,include integrating the modeling factors of CAG with of deficiency syndrome,and integrating the modeling factors of deficiency syndrome with of CAG.

Key words: Rat, CAG, Animal model of combining disease with symptom, Design about how to establish the model

摘要： 目的　使大鼠慢性萎缩性胃炎 (CAG)证病结合模型更好地模拟临床病、证和症病结合的实际。造模方法的设计思路 :①慢性造模 :“慢性”并非仅为疾病的一个简单性质 ,由于它为时间维度 ,而使疾病病理立体化。所以 ,本实验证、病和症病结合模型均选择较长的造模时间。结果显示各实验组动物胃粘膜均未见出血及溃疡、糜烂 ,各脏器组织不以渗出、坏死为主要病理。②CAG造模 :癌前病变乃至癌变只是虚证的结果和终点 ,致癌物质只是致虚物质的特例。因此 ,我们尽量采用一般的致CAG因素而非致癌物质来诱发肠化病理。在CAG证病结合模型的评价上还注意与CAG相关的机体整体性变化。③证候造模 :脾虚证、肝郁证、肾虚证造模方法均为较成熟方法 ,又均据本实验要求和预试验结果 ,延长了造模时间。④证病结合造模 :临床未将肾虚证作为CAG的主要证候 ,我们依据对肾虚证本质的反重演律理解 ,认为CAG ,特别是有癌前病变的CAG其病理本质应是肾虚证。并注意了病与证的造模因素应尽量达到有机结合 ,包括 :CAG造模因素与虚证造模的一致性 ;虚证造模因素与CAG造模的一致性

关键词: 大鼠, CAG, 证病结合模型, 造模思路