Abstract: Objective\ To evaluate the therapeutic effects of Bleomycin A 6(BLMA 6) and cis\|platium Diamino\|Dichl\|Pride(DDP) on human esophageal adenosquamous carcioma and squamous carcinoma.Methed\ Two xenofrafts were treated with the same drug and every tumor xenograft was treated with both agents.Result\ Bleomycin A\-6 can reduce the growth of HEC\-2 and HEC\-6 and there is no apparent side effects in experimental animals.DDP only reduce the growth of HEC\-6.Conclusion\ Blemycin A\-6 is more effective than DDP in the treatment of human esophageal adenosquamous carcinoma and aquamous carcinoma.

Key words: Esophageal carcinoma, Xenograft in nude, Bleomycin, cis platium Diamino Dichl Pride(DDP)

摘要： 目的　用抗癌药物博莱霉素 (BLMA6 )和顺氯氨铂 (DDP)对人食管鳞癌 (HEC2 )和人食管腺鳞癌 (HEC6 )两种裸鼠移植瘤株进行治疗的研究。方法　用同一种药物对两种不同瘤株进行治疗 ;用不同药物治疗同一种瘤株 ,以此进行药物疗效的比较。结果　BLMA6 对HEC2 和对HEC6 均有显著的抑制作用。DDP对HEC6 有一定的抑制作用 ,而对HEC2 的作用不明显。BLMA6 在显著抑制肿瘤生长的剂量下 ,对内脏无明显损害。结论　对人食管鳞癌和腺鳞癌的治疗BLMA6 优于DDP。

关键词: 食管癌, 裸鼠移植瘤, 博莱霉素, 顺氯氨铂